Liquid–liquid phase separation underpins the formation of replication factories in rotaviruses.
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Geiger F, Acker J, Papa G, Wang X, Arter WE, Saar KL, Erkamp NA, Qi R, Bravo JPK, Strauss S, Krainer G, Burrone OR, Jungmann R, Knowles TPJ, Engelke H, Borodavka A (2021). Structural basis of rotavirus RNA chaperone displacement and RNA annealing. Uncover the molecular architecture of viral RNA assembly sites and identify their essential components.ĭissect the molecular mechanisms underlying the formation of viral factories and their molecular selectivity.īravo JPK, Bartnik K, Venditti L, Acker J, Gail EH, Colyer A, Davidovich C, Lamb DC, Tuma R, Calabrese AN, Borodavka A (2021). Identify RNA sequences that mediate RNA genome assembly. Understand the roles of viral RNA chaperones in the process of RNA assembly during viral infection. To achieve this, we use a combination of single-molecule fluorescence techniques, RNA imaging and structure probing. Our goal is to find out how rotaviruses select the right gene segments by exploring their individual structures and how they interact with each other. Despite the importance of understanding the molecular basis of segmented RNA genome packaging, there is very little knowledge of how eleven distinct RNAs are selected in rotaviruses. It is not clear how rotaviruses 'count' up to 11 so that each new virus acquires a single copy of each segment.
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During rotavirus replication, RNA segments are copied many times. Most children will be infected at least once by the age of five, and that means there are a huge number of cases every year – estimated at over 114 million – with upwards of 200,000 deaths. Rotaviruses are highly contagious pathogens that mainly infect children. Molecular mechanisms underpinning RNA-controlled self-assembly of multi-segmented viral genomes.